Publications

1. T Huo, H Wu, Z Moussa, M Sen, V Dalton, Z Wang. "Full-length αIIbβ3 cryo-EM structure reveals intact integrin initiate-activation intrinsic architecture". Structure, 2024, 2024. PMID: [PMID].
2. M Sen. "Interplay between intrinsic flexibility and sugar coating in Contactin-2 homodimerization". Structure 32 (1), 3-5, 2024, 2024. PMID: [PMID].
3. M Martinez-Vargas, J Courson, L Gardea, M Sen, A Yee, R Rumbaut, .... "The impact of von Willebrand factor on fibrin formation and structure unveiled with type 3 von Willebrand disease plasma". Blood Coagulation & Fibrinolysis, 10.1097, 2024, 2024. PMID: [PMID].
4. S Verma, FT Ogata, IY Moreno, CP da Silva, TD Marforio, M Calvaresi, .... "Rational design and synthesis of lumican stapled peptides for promoting corneal wound healing". The Ocular Surface 30, 168-178, 2023, 2023. PMID: [PMID].
5. JEE Pinelo, P Manandhar, G Popovic, K Ray, MF Tasdelen, Q Nguyen, .... "Systematic mapping of the conformational landscape and dynamism of soluble fibrinogen". Journal of Thrombosis and Haemostasis 21 (6), 1529-1543, 2023, 2023. PMID: [PMID].
6. S Nandy, VM Maranholkar, M Crum, K Wasden, U Patil, A Goyal, B Vu, .... "Expression and Characterization of Intein-Cyclized Trimer of Staphylococcus aureus Protein A Domain Z". International journal of molecular sciences 24 (2), 1281, 2023, 2023. PMID: [PMID].
7. P Manandhar, Z Mazhar, O Abousaway, C Aboagye, Z Moussa, D Lim, .... "Heterotropic roles of divalent cations in the establishment of allostery and affinity maturation of integrin αXβ2". Cell reports 40 (8), 2022, 2022. PMID: [PMID].
8. RK Jensen, G Bajic, M Sen, TA Springer, T Vorup-Jensen, GR Andersen. "Complement receptor 3 forms a compact high-affinity complex with iC3b". The Journal of Immunology 206 (12), 3032-3042, 2021, 2021. PMID: [PMID].
9. X Liu, Y Wang, J Wu, J Qi, Z Zeng, Q Wan, Z Chen, P Manandhar, .... "Neutralizing aptamers block S/RBD‐ACE2 interactions and prevent host cell infection". Angewandte Chemie International Edition 60 (18), 10273-10278, 2021, 2021. PMID: [PMID].
10. S Fannin, J Rangel, AP Bodurin, T Yu, B Mistretta, S Mali, P Gunaratne, .... "Functional and structural characterization of Hyp730, a highly conserved and dormancy‐specific hypothetical membrane protein". MicrobiologyOpen 10 (1), e1154, 2021, 2021. PMID: [PMID].
11. V Kayser, M Sen. "New Emerging Biotherapies: Cutting‐Edge Research to Experimental Therapies". Biologics, Biosimilars, and Biobetters: An Introduction for Pharmacists …, 2020, 2020. PMID: [PMID].
12. G Saggu, K Okubo, Y Chen, R Vattepu, N Tsuboi, F Rosetti, X Cullere, .... "Cis interaction between sialylated FcγRIIA and the αI-domain of Mac-1 limits antibody-mediated neutrophil recruitment". Nature communications 9 (1), 5058, 2018, 2018. PMID: [PMID].
13. S Hiramitsu, T Ishikawa, WR Lee, T Khan, C Crumbley, N Khwaja, .... "Estrogen receptor beta-mediated modulation of lung cancer cell proliferation by 27-hydroxycholesterol". Frontiers in endocrinology 9, 470, 2018, 2018. PMID: [PMID].
14. K Kurakula, DS Koenis, MA Herzik Jr, Y Liu, JW Craft Jr, PB van Loenen, .... "Structural and cellular mechanisms of peptidyl-prolyl isomerase Pin1-mediated enhancement of Tissue Factor gene expression, protein half-life, and pro-coagulant activity". Haematologica 103 (6), 1073, 2018, 2018. PMID: [PMID].
15. M Sen, AC Koksal, K Yuki, J Wang, TA Springer. "Ligand-and cation-induced structural alterations of the leukocyte integrin LFA-1". Journal of Biological Chemistry 293 (17), 6565-6577, 2018, 2018. PMID: [PMID].
16. ZS Wilson, LB Ahn, WS Serratelli, MD Belley, J Lomas-Neira, M Sen, .... "Activated β2 Integrins Restrict Neutrophil Recruitment during Murine Acute Pseudomonal Pneumonia". American Journal of Respiratory Cell and Molecular Biology 56 (5), 620-627, 2017, 2017. PMID: [PMID].
17. M Sen, TA Springer. "Leukocyte integrin αLβ2 headpiece structures: The αI domain, the pocket for the internal ligand, and concerted movements of its loops". Proceedings of the National Academy of Sciences 113 (11), 2940-2945, 2016, 2016. PMID: [PMID].
18. F Rosetti, Y Chen, M Sen, E Thayer, V Azcutia, JM Herter, FW Luscinskas, .... "A lupus-associated Mac-1 variant has defects in integrin allostery and interaction with ligands under force". Cell reports 10 (10), 1655-1664, 2015, 2015. PMID: [PMID].
19. M Sen, K Yuki, TA Springer. "An internal ligand-bound, metastable state of a leukocyte integrin, αXβ2". Journal of Cell Biology 203 (4), 629-642, 2013, 2013. PMID: [PMID].
20. K Yuki, M Sen, T Springer. "Common activation mechanism of beta 2 integrins (P5073)". The Journal of Immunology 190 (1_Supplement), 129.1-129.1, 2013, 2013. PMID: [PMID].

Posters

Bold — poster presenter. — awarded.

1. Castillo M, Şen M & Kayser V. Utilizing N-glycans to develop aggregation resistant monoclonal antibodies. 24th Annual Structural Symposium, University of Texas Medical Branch, Galveston, TX, May 2019.
2. Manandhar P, Liu Y, Rajarathnam K, Yuki K, Briggs J & Şen M. Molecular basis of simvastatin binding to integrin α_Xβ₂. 24th Annual Structural Symposium, University of Texas Medical Branch, Galveston, TX, May 2019.
3. Abousaway O, Aboagye C, Rajarathnam K & Şen M. Triple resonance NMR backbone assignment of the ligand binding domain of the α_Xβ₂ integrin. 24th Annual Structural Symposium, University of Texas Medical Branch, Galveston, TX, May 2019.
4. Moussa Z, Mazhar Z, Yuki K, Briggs J & Şen M. Identifying an activating glycan mutant in α_X subunit of α_Xβ₂ integrin. 24th Annual Structural Symposium, University of Texas Medical Branch, Galveston, TX, May 2019.
5. Bodunrin A, Wang T, Şen M & Widger W. Biophysical & structure properties of the UspA712 of Micrococcus luteus. 24th Annual Structural Symposium, University of Texas Medical Branch, Galveston, TX, May 2019.
6. Fannin S, Rangel J, Widger W & Şen M. Purification and initial characterization of a hypothetical membrane protein. 24th Annual Structural Symposium, University of Texas Medical Branch, Galveston, TX, May 2019.
7. Rangel J, Şen M & Widger W. Can activation of Rho factor through RNA binding-induced ring closure be identified by cryo-EM? 24th Annual Structural Symposium, University of Texas Medical Branch, Galveston, TX, May 2019.
8. Dairywala M, Manandhar P, Aboagye C, Yu T & Şen M. Structural characterization of leukocyte integrin α_M I-domain. Undergraduate Research Day, University of Houston, Houston, TX, October 2018.
9. Manandhar P, Aboagye C, Le T & Şen M. Probing conformational changes and stability of the ligand binding site of integrin α_Xβ₂. 23rd Annual Structural Symposium, University of Texas Medical Branch, Galveston, TX, April 2018.